Biochemical Factors Concerned in the Functional Activity of by D. Richter

By D. Richter

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Extra resources for Biochemical Factors Concerned in the Functional Activity of the Nervous System. First International Meeting of the International Society for Neurochemistry, Strasbourg, 1967

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74 l^moles/g in animals exposed to hypoxia for 20 minutes and allowed to recover. The hamster was found to be a very suitable animal to use for sleep studies since it is less easily roused than the rat. Of the amino acids analysed, glutamic acid, alanine and GABA showed a small decrease in concentration in the hamster brain during undisturbed natural sleep of at least thirty minutes duration. During hibernation in the hamster, the brain levels of threonine, alanine and GABA increased, whilst those of glutamic acid and lactic acid decreased.

During hibernation in the hamster, the brain levels of threonine, alanine and GABA increased, whilst those of glutamic acid and lactic acid decreased. GODIN, Y. & MANDEL, P. (1965). J. , 12, 455. RICHTER, D. C. (1948) . Amer. J. Physiol. , 154 » h* THE EFFECT OF X-IRRADIATION ON THE METABOLISM OF THE DEVELOPING CENTRAL NERVOUS SYSTEM Stanley Cohan and Donald H. Ford Department of Anatomy, State University of New York Downstate Medical Center, Brooklyn, New York We have undertaken a series of experiments to determine the effect of X-irradiation of neonatal rat brain on the metabolism of triiodothyronine (To) in the central nervous system (CNS) at different stages of postnatal development.

In contrast, ribosomes showed only trace aminopeptidase and arylamidase activities with these substrates, which indicated that most of the enzymic activity in the microsomal fraction resided in the membrane portion. On the basis of substrate specificity and enzyme stability, effects of SH- and oxidizing agents. and pH optima, indications were obtained of the presence of a multiple enzyme system for peptide breakdown in the microsomal membrane fraction. 5$· desoxycholate, dialysis, and repeated passage through DEAE and CM columns.

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