Chromosome Nanoscience and Technology by Kiichi Fukui, Tatsuo Ushiki

By Kiichi Fukui, Tatsuo Ushiki

Regardless of development in genetic learn, wisdom in regards to the precise constitution of the chromosome maintains to supply a problem. a lot of that problem lies with the necessity for more suitable instruments and strategies that researchers require to accomplish novel analyses past the DNA point. thankfully, speedy advances in nanotechnology, are actually being hired to check, examine, and control organic fabric on the chromosome point.

Chromosome Nanoscience and Technology studies those advances and their contribution to tendencies and purposes in chromosome study. as well as providing a advisor to present growth, this ebook serves because the culminating record on a jap nanobiology undertaking within the box of chromosome technological know-how all started in 2000.

The venture introduced jointly researchers from disparate backgrounds that integrated molecular biology, biochemistry, protein technology, immunology, genetics, anatomy, semiconductor construction, polymer chemistry, fabric technological know-how, microscopy, and informatics, between others. chromosomes as nanomaterials, their contributions conceal:

  • Devices for chromosome dealing with, which contains the development and program of nano and micro units used for dissecting, studying, and manipulating chromosomes
  • Visualization of chromosomes at nano and micro levels, which discusses tools for revealing nano-level folding of chromatin fibers
  • Chromosomes as nanomaterials, which provides a brand new chromosome protein framework in accordance with the cataloging of over two hundred chromosomal proteins
  • Informatics of chromosome images, which examines a brand new chromosome photo database procedure for animals and plants
  • This undertaking, initiated many years in the past, now lays the foundation for these scientists trying to practice additional learn in chromosome technological know-how. It presents them with beginning issues, in addition to invaluable functions and technique to aid within the lengthy quest to achieve a deepened realizing of existence itself.

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    Chromosome Nanoscience and Technology

    Regardless of growth in genetic learn, wisdom concerning the specified constitution of the chromosome keeps to supply a problem. a lot of that problem lies with the necessity for greater instruments and strategies that researchers require to accomplish novel analyses past the DNA point. thankfully, speedy advances in nanotechnology, at the moment are being hired to check, research, and control organic fabric on the chromosome point.

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    Thus, specific DNA amplification from chromosomes was possible on the microchamber chip. We then attempted trace volume PCR amplification from a single chromosome using the microchamber. For the certain collection and distribution of a chromosome from the chromosome sample on the substrate to the microchamber, the tweezer-type probe, which was developed for the AFM manipulation described elsewhere (see Chapter 2), was suitable. 6[a]). The positions of the glass capillary and the tweezer probe tips were controlled using the micromanipulator (Eppendorf, Switzerland), which was attached to the optical or metal surface microscope.

    We have achieved the dissection of DNA and chromosomes using the knife-edged probe under AFM operation. Moreover, the collection of fragments of the metaphase chromosome, which was dissected with the knife-edged probe, was possible using our tweezertype probe. It is indicated that the nanoscale manipulation of biological samples, especially chromosomes, has become possible, and further analysis of the specific portion of a chromosome can be performed using established analytical methods. Acknowledgment The authors gratefully acknowledge that this study was supported in part by a grant from the Special Coordination Funds for Promoting Science and Technology of the Ministry of Education, Culture, Sports, Science and Technology, the Japanese government.

    Guthold M, Falvo M, Matthews WG, Paulson S, Mullin J, Lord S, Erie D, Washburn S, Superfine R, Brooks FP Jr, Taylor II RM (1999) Investigation and modification of molecular structures with the nanomanipulator. J Mol Graph Model 17: 187–197.  Geisler B, Noll F, Hampp N (2000) Nanodissection and noncontact imaging of plasmid DNA with an atomic force microscope. Scanning 22: 7.  Fotiadisa D, Scheuringa S, Mullera SA, Engela A, Muller DJ (2002) Imaging and manipulation of biological structures with the AFM.

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