Current Topics in Medical Mycology by Marcel Borgers (auth.), Michael R. McGinnis Ph.D. (eds.)

By Marcel Borgers (auth.), Michael R. McGinnis Ph.D. (eds.)

Contents: Ultrastructural Correlates of Antimycotic Treatment.- Soluble Polysaccarides of Cryptococcus neoformans.- Tinea Imbricata.- Adhesion and organization Mechanisms of Candida albicans.- Peptide shipping in Candida albicans: Implications for the improvement of Antifungal Agents.- Epidemiology of Coccidioidomycosis.- Immune reaction to Paracoccidioides brasiliensis in Human and Animal Hosts.- Morphogenetic Transformation of Fungi.- Epidemiology of Nosocomial Fungal Infections.- Melanins and Their significance in Pathogenic Fungi.- Cytochrome P-450 of Fungi: fundamental goal for Azole Antifungal Agents.- Index.

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72. 73. 74. 75. 76. 77. 78. 79. 80. 81. M. Borgers mechanisms of action of c1otrimazole on Candida albicans. Sabouraudia 11 :205-209,1973. 349), a new imidazole derivative. Antimicrob Agents Chemother 15: 597-602, 1979. Karaoui R, Bou-Resli M, AI-Zaid NS, Mousa A: Tinea versicolor: Ultrastructural studies on hypopigmented and hyperpigmented skin. Dermatologica 162: 69-85, 1981. Kanazawa T: Antimycotic action of A diamidine compound, 1, 4-bis-(M,M'amidinophenoxymethyl)-cyc1ohexane dilactate on Candida albicans.

Povidone-iodine preparations are reported to be efficacious in pityriasis versicolor and ringworm infection. A scanning electron microscopic study revealed swelling of fungal elements; however, a direct relation between the observed changes and mode of action ofthe treatment has not been shown (72). The effects of 4, bis-(m,m'-amidinophenoxy methyl)-cyclohexane dilactate (MAC), a diamidine compound, against C. albicans have been studied by freeze-fracture electron microscopy (65). MAC caused aggregation of membrane particles and patch formation on the P face, which suggest that the drug causes membrane disruption.

It is convenient to refer to this family of antigens as glucuronoxylomannans. Structural models based on methylation-fragmentation analysis showed that the major capsular polysaccharides are composed of a linear backbone of (I-+3)-linked Dmannopyranosyl (manp) residues substituted with D-xylopyranosyl (xylp) and glucopyranosyluronic acid (glcpA) nonreducing termini (2,3,4,5,18,46) (Scheme 2-1). Serotypes A and D (3, 6, 18,46) are substituted at 0-2 only, whereas serotypes Band C (2, 4, 5) are substituted with xylp at 0-4 as well as at 0-2 (Scheme 2-1).

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