Industrial and Environmental Xenobiotics: Metabolism and by L. Magos (auth.), Ivan Gut M.D., Ph.D., Miroslav Cikrt M.D.,

By L. Magos (auth.), Ivan Gut M.D., Ph.D., Miroslav Cikrt M.D., Ph.D., Professor Gabriel L. Plaa Ph.D. (eds.)

The booklet you're simply going to learn represents the better a part of the papers awarded on the foreign convention on business and En­ vironmental Xenobiotics, held in Prague, 1980, and a few contributions by way of those that couldn't come. the 1st goal of the assembly used to be to fol­ low the culture arrange by way of the 1st convention in 1977. back, we in­ vited biochemists, pharmacologists, and toxicologists from either East and West, who have been curious about the examine of disposition, biotransforma­ tion, and toxicity of significant types of commercial and environmental pollution, to advertise the trade of principles and evaluations on priorities during this zone of the learn of human setting. The invited contributions provide a good survey of and professional­ discovered perception into particular parts of toxicology and disposition of metals and natural chemical substances, and the sequence of papers on particular topics convey clean info at the biotransformation and mechanisms of poisonous motion of numerous industrially vital solvents tmd monomers of plastics. instead of from the Preface, the reader should still search tips from the Index, which truly exhibits the overlapping of this quarter of toxicology with the most recent ends up in biochemistry. We gratefully recognize the certainty, care, and preciSion of the writer that made this e-book attainable. The Editors Contents Metals Metabolic components within the Distribution and part Time of Mercury After publicity to diversified Mercurials 1. Magos. With 1 determine . . . . . . . . . . . . . . . . . . .. . . . 1 . . . . . Biliary Excretion of Metals M. Cikrt. With nine Figures. . . . . . . . . . . . . . . . . . . .. . . 17 . . . . .

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Extra resources for Industrial and Environmental Xenobiotics: Metabolism and Pharmacokinetics of Organic Chemicals and Metals Proceedings of an International Conference held in Prague, Czechoslovakia, 27’30 May 1980

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Acta Pharmacol Toxicol43:205-210 Stowe HD (1976) Biliary excretion of cadmium by rats: effect of zinc, cadmium and selenium pretreatments. J Toxieol Environ Health 2:45-53 Terao T, Owen CA Jr (1973) Nature of copper compounds in liver supernate and bile of rats: studies with • 7CU. Am J Physiol 224:682-686 Tiehy M, Cikrt M, Havrdova J (1973) Manganese binding in rat bile. Arch Toxikol 30: 227 -236 Tichy M, Havrdova J, Cikrt M (1975) Comments on the mechanism of excretion of mercury compounds via bile in rats.

66 Klaassen (1973) Klaassen (1975a) Klaassen and Kotsonis (1977) Lener and Bibr (1979) Klaassen (1975a) compounds is believed to be that of active transport. The active transport system is characterized by classical properties: transport against the concentration or electrochemical gradient, saturation of the process, selectivity of the system, and requirement of the energy expenditure. In the study of active transport of substances into bile all the criteria have seldom been fulfIled. In our opinion there is also a possibility that there could be involved some passive processes in the mechanism of the biliary excretion of metals, especially very shortly after an intravenous injection of metal, when its concentration in the blood is relatively high.

Klaassen (1975b); 7. Klaassen (1975a); 8. Haddow et aI. (1972); 9. Cikrt (1978); 10. Norseth (1973b) Table 14. Substances affecting biliary excretion of Cd 2+ Element Substance Effect Reference Spironolactone 0- 0 0 0 Klaassen and Kotsonis (1977) Kitani et aI. (1977a) Klaassen (1979a) Klaassen and Kotsonis (1977) Klaassen and Kotsonis (1977) Kojima et al. (1976) Kojima et aI. (1976) Kojima et aI. (1976) Cherian (1980) Kojima et aI. (1976) Kojima et aI. (1976) Kojima et aI. (1976) Klaassen and Kotsonis (1977) Cherian (1980) Cherian (1980) 0 Cherian (1980) 3-methyicholanthrene Phenobarbital EDTA Citric acid 2,3-dimercaptopropan 01 L-cysteine D-cysteine D,L-penicillamine Pregnenoione-16a-carbonitri1e Diethylenetriamine pentaacetic acid 2,3-dimercapto-i-propanesulfonic acid, sodium salt 1,3-dimercaptopropanoi + Increase of biliary excretion - Decrease of biliary exaetion o Without effect 0 + + 0 + + 30 M.

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