By Morris F. White (auth.), Ashok K. Srivastava, Barry I. Posner (eds.)
In 1996 the seventy fifth anniversary of the invention of insulin was once celebrated on the college of Toronto, the scene of that discovery in 1921. This quantity was once prompted by way of the clinical software which used to be staged at the moment and taken jointly a lot of the world's most sensible expertise to debate and study the latest advancements in our figuring out of pancreatic functionality, insulin secretion, the interplay of insulin with its goal tissues, the mechanism of insulin motion on the mobile point, and the defects which underlie either sort I (insulin-dependent diabetes mellitus, IDDM) and kind II (noninsulin-dependent diabetes mellitus, NIDDM) different types of the ailment. we've selected to concentration the current quantity on paintings regarding insulin action.
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Additional resources for Insulin Action
The protein (ser/thr) kinase known as KSR was first identified in Drosophila and C. elegans through a screen for suppressor mutants of activated Ras alleles [48,49]. Mammalian KSR has recently been identified as a ceramide-acti vated kinase that is capable of phosphorylating and activating cRaf-1 in vitro [501. Thus KSR may participate in the activation of Raf by TNFa and related ligands that generate ceramide in situ. Other candidate Raf-activating kinases include PKCa [511 and Src family nonreceptor tyrosine kinases .
It is plausible that the protein (ser/thr) kinases, already established in unicellular organisms as versatile elements for transducing signals from the cell surface to the cell interior that regulate cell growth and differentiation, were co-opted into the service of the receptor tyrosine kinases. This review will summarize the evolution of our present concepts of insulin action, current information on the protein (ser/thr) kinase cascades and their status as mediators of insulin signal transduction.
Proc Natl Acad Sci USA 90: 4460-4464, 1993 Berghe NVD, Ouwens DM, Maassen JA, Mackelenbergh MGH, Sips HCM, Krans HMJ: Activation of the Ras/mitogen-activated protein kinase signalling pathway alone is not sufficient to induce glucose uptake in 3T3-L I adipocytes. Mol Cell Bioi 14: 2372-2377, 1994 Hausdorff SF, Frangioni JV, Birnbaum MJ: Role ofp21ras in insulinstimulated glucose transport in 3T3-L I adipocytes. J BioI Chem 269: 21391-21394,1994 Reusch JE-B, Bhuripanyo P, Carel K, Leitner JW, Hsieh P, DePaolo D, Draznin B: Differential requirement for p21ras activation in the metabolic signalling by insulin.