By Derek Crowther (auth.), Professor Derek Crowther (eds.)
A good deal of recent info has been acquired in the past 4 years, and this monograph presents a transparent and good reviewed replace on biochemical mechanisms and the result of very important new medical stories utilizing the interferons. experiences contain what's almost immediately identified concerning the biosynthesis, physiological function and mechanisms of motion of the interferons (alpha, beta, gamma). New biochemical info on interferon-receptor interactions and signalling pathways is equipped. The pharmacokinetic issues in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and different strong tumors are reviewed with particular emphasis on stories of adjuvant chemotherapy in malignancies of the immune system.
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Extra info for Interferons: Mechanisms of Action and Role in Cancer Therapy
The preliminary results of both can be summarised as follows: the addition of interferon to chlorambucil has not improved the respqnse rate or the complete response rate. As expected, the combination is associated with a greater degree of myelosuppression than chlorambucil alone. However, significantly fewer relapses have been observed in patients receiving maintenance interferon, although as yet there is no survival advantage. In the British study, the 'best results' have been seen in the patients receiving interferon throughout .
Non-recombinant IFNs IFN-a IFN-a IFN-a 3 4 3 6 8 18   [11 ]     Recombinant IFNs IFN-aA IFN-aA· IFN-aA IFN-aA· 4 13 17 9 24 15 30 TOTAL 53 120 6 • previously untreated patients 36 A. Rohatiner In a French study, when interferon was prospectively compared with prednimustine (a combination of prednisolone and chlorambucil) and an expectant policy, in newly diagnosed patients with follicular lymphoma deemed not to be in need of urgent treatment, a somewhat higher response rate (74%) was observed (which was the same as that for prednimustine) .
001). There is now substantial evidence showing the superiority of chemotherapy in combination with alpha-IFN for response induction in myeloma as compared to chemotherapy alone. The results of the Italian Multiple Myeloma Study Group and of the present MGCS study support the notion that alphaIFN may also have an impact on survival. Acknowledgements This study was supported by grants from the Swedish Cancer Society and the Cancer Society in Stockholm. For excellent secretarial help we thank Ms Marie Karlsson.