Molecular Mechanisms of Hormone Action by P. Karlson (auth.), Prof. Dr. Ulrich Gehring, Prof. Dr.

By P. Karlson (auth.), Prof. Dr. Ulrich Gehring, Prof. Dr. Ernst J. M. Helmreich, Prof. Dr. Günter Schultz (eds.)

Recent years have noticeable large development within the box of hormone motion and consequent sign transduction. The fortieth Colloquium Mosbach was once dedicated to the dialogue of effects in regards to the molecular means of hormone motion, in particular the techniques following hormone binding to the corresponding receptors. Structural and sensible elements of steroid hormone receptors in addition to ion-channel-coupled and enzyme-linked receptors have been taken care of intimately. specific curiosity focussed at the most modern effects touching on transcriptional keep watch over, protein phosphorylation, the position of G-Proteins, oncogene proteins, involvement of phospholipases and the law of ion channels.

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Extra resources for Molecular Mechanisms of Hormone Action

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And implies that thyroid and steroid hormones regulate the activities of their receptors through a similar mechanism. Comparing the activities of the various hybrid receptors provides insight into the regions ofthe receptors that are responsible for trans-activation. Removal of the amino terminus of either thyroid hormone receptor has little impact on the ability of these receptors to activate this promoter (Fig. 2, unpublished observations). This suggests that the thyroid hormone receptors do not have a trans-activation function in their amino terminus but may, like the glucocorticoid and estrogen receptors (Hollenberg and Evans 1988; Webster et al.

According to this model, the primary function of DNA is simply to organize recognition sites for the various regulatory proteins in such a way that kinetically favorable protein-protein interactions can occur. That is, the DNA serves as a two-dimensional "string," assembling recognition sites for the appropriate factors in space so that the local concentration exceeds that required to facilitate assembly of the initiating complex. Fig. 1. L. Hager 30 Not related to A) Processive transcription activation ~ §' NA-+ Polymerase ~ a B) Access 'Potentially' involved in expression control Fig.

988) Characterization of a thyroid hormone receptor expressed in human kidney and other tissues. Proc. Natl. Acad. Sci. H. (\983) The nuclear receptor-triiodothyronine complex: relationship to thyroid hormone distribution, metabolism, and biological action. In: Oppenheimer. H. H. (eds) Molecular basis of thyroid hormone action. Academic Press, New York London, pp. , & Surks. I. (\974) Tissue differences in the concentration of triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary.

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