Purine and Pyrimidine Metabolism in Man V: Part B: Basic by Winand N. M. Dinjens, Rineke van Doorn, Jan P. R. M. van

By Winand N. M. Dinjens, Rineke van Doorn, Jan P. R. M. van Laar-hoven, Dirk Roos (auth.), W. L. Nyhan, L. F. Thompson, R. W. E. Watts (eds.)

The 5th foreign Symposium on Human Purine and Pyrimidine Metabolism was once held in San Diego, California (U. S. A. ) in July and August of 1985. prior conferences during this sequence have been held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The complaints of every of those conferences have been released via Plenum. the subsequent assembly may be in Japan. This Symposium differed from those who went ahead of in that it according to­ mitted us to honor Dr. J. E. Seegmiller, Professor of drugs on the college of California San Diego, for his many contributions to our knowing of purine metabolism in guy. This ebook is devoted as a Festschrift to Jay. Dr. Richard W. E. Watts introduced the keynote tackle outlining in scholarly type the historical past of Dr. Seegmiller's accomplishments in learn on purine metabolism and the good variety of at present lively scientists during this box who've labored with him. This tackle is released because the first contribution to quantity I. Dr. Dewitt Stetten, Jr. , used to be scheduled to be the speaker at our dinner party. unlucky­ ly, he couldn't be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our box, and this has been pub­ lished following Dr. Watts' paper. the expansion of data in purine and pyrimidine metabolism remains to be exponential. the diversity of topics incorporated in those volumes is impressive.

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D. L. Marquardt, H. E. Gruber, and S. I. Wasserman, Adenosine release from stimulated mast cells, Proc. Natl. Acad. Sci. USA. 81:6192 (1984) 2. D. L. Marquardt, C. W. Parker, and T. J. Sullivan, Potentiation of mast cell mediator release by adenosine, J. Immunol. 120:871 (1978). R. L. Sabina, K. H. Kernstine, R. L. Boyd, E. W. Holmes, and J. L. Swain, Metabolism of 5-amino-4imidazolecarboxamide riboside in cardiac and skeletal muscle, ~. BioI. Chem. 257:10178 (1982). 3. 4. D. L. Marquardt, L. L.

4)(5) Snyder et al(6) suggested that MTA stimulates the adenosine receptor. There are many reports that, in the human subjects, many cells including tracheal smooth muscle cells, have the adenosine receptor. (7) The action of adenosine on tracheal muscle cells in vitro has been intensively investigated(8) , but there are no reports concerning the action of MTA on tracheal smooth muscle preparations. In this experiment, we studied the effect of MTA on isolated guinea pig tracheal strips and the mechanisms that may mediate this are discussed.

Allergy appl. Immunol. 74: 356 (1984). 29. G. Marone, M. Columbo, L. Soppelsa, and M. Condorelli, The mechanism of basophil histamine release induced by pepstatin A, J. Immunol. 133: 1542 (1984). 30. S. W. P. P. H. M. Lichtenstein, Human lung mast cells: purification and characterization, J. Immunol. 129: 2662 (1982). 31. W. P. P. S. K. H. M. Lichtenstein, Generation of leukotrienes by purified human lung mast cells, J. Clin. Invest. 70: 747 (1982). 32. S. Hammarstram, Leukotrienes, in: Advances in Clinical Immunology.

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