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Additional resources for Smart Materials for Tissue Engineering: Fundamental Principles
1). These key processes are regulated by the extracellular environment, which consists of a physical network of proteins and proteoglycans, and also involves nonmatrix soluble components, such as growth factors. 53,54 This section describes specific factors, such as the composition of cell adhesion proteins, ECM topography, and ECM stiffness, that work as local microenvironmental cues and are important for designing smart materials, rather than soluble and highly diffusive factors. 1 Composition of Cell Adhesion Proteins The extracellular microenvironment that surrounds cells is a highly hydrated network that includes molecular signals.
A) Smart materials are designed in two steps via modulation of the spatiotemporal organization of cell adhesion complexes and the actin cytoskeleton. (B) Strategy for controlling adhesion complexes and the actin cytoskeleton by tuning material topography and stiffness. The spatial distribution of adhesion complexes and the number and orientation of the actin stress fibers can be definitely modulated. Stiffness (abscissa) is a parameter that affects the magnitude of the restriction effect of topographical features.
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